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<title>Efficacy of phonophoresis therapy in plasma antioxidant status on freund&rsquo;s adjuvant induced arthritic rats</title>
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  <h2 align="center" class="style6">Volume <span class="style11">4</span>, Issue10</h2>
	    <h6 align="center" class="style1"><strong></strong><strong></strong><strong>Efficacy of phonophoresis therapy in plasma antioxidant  status on freund&rsquo;s adjuvant induced arthritic rats</strong><br />
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	    <p><strong>Author:</strong> P. Lakshmi Kanth, V. Elango</p>
<p><span class="style10">Abstract: </span>Antioxidant profiles of plasma can provide important information about the defense mechanism of an organism. In the present  investigation the effect of ultrasound  and phonophoresis on  the plasma antioxidant is determined in Freund&rsquo;s adjuvant induced arthritic rats. The increased MDA content and decreased in superoxide  dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non enzymatic  antioxidant, such as glutathione (GSH), vitamin C and vitamin E in arthritic  rats were observed  in the present investigation, due to increased free radical in arthritis rats. The result of the present experiment indicates that phonophoresis  therapypossesses significant antioxidant activity as compared with  ultrasound application. The possible mode of action of antioxidant activity of  phonophoresis therapy appears to be enhanced membrane permeability and inhibit  the free radical formation and thereby improving antioxidant parameters. Thus,  the increase in superoxide dismutase (SOD), catalase (CAT), glutathione  peroxidase (GPx) and non enzymatic antioxidant, such as glutathione (GSH)  brought about by ultrasound and phonophoresis treatment further support its  antioxidant effect. The potential phonophoresis therapy might be due to various  ingredients in <em>Plumbago zeylanica </em>extractacting synergistically  and working in concert for overall antioxidant activity.</p>
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