| Server IP : 192.169.170.185 / Your IP : 216.73.216.97 Web Server : Apache System : Linux p3plmcpnl495852.prod.phx3.secureserver.net 4.18.0-553.52.1.lve.el8.x86_64 #1 SMP Wed May 21 15:31:29 UTC 2025 x86_64 User : akhilnew ( 1712764) PHP Version : 5.6.40 Disable Function : NONE MySQL : ON | cURL : ON | WGET : ON | Perl : ON | Python : ON | Sudo : OFF | Pkexec : OFF Directory : /home/akhilnew/public_html/thepharmajournal/vol4Issue10/ |
Upload File : |
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Strict//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-strict.dtd">
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
<head>
<meta name="Description" content="The main purpose of this study was to increase the solubility of poorly soluble drug by preparing solid dispersions."/>
<meta name="keywords" content="Nifedipine, solid dispersion, co-milling, solvent loading."/>
<title>Preparation and in-vitro evaluation of nifedipine amorphous solid dispersions using mesoporous silica gel</title>
<meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1" />
<meta name="Distribution" content="Global" />
<meta name="Author" content="Erwin Aligam - ealigam@gmail.com" />
<meta name="Robots" content="index,follow" />
<link rel="stylesheet" href="images/FreshMedia.css" type="text/css" />
<style type="text/css">
<!--
.style1 {
font-size: 16px;
color: #FF0033;
}
.style4 {color: #FF0033}
.style5 {color: #000000}
.style3 {
color: #FF0000;
font-weight: bold;
}
.style6 {
color: #000000;
font-weight: bold;
}
.style10 {color: #FF0033; font-weight: bold; }
.style11 {font-family: "Times New Roman", Times, serif}
.style12 { font-size: 14px;
font-weight: bold;
}
.style13 {color: #FF0000}
-->
</style>
</head>
<script type="text/javascript">
var _gaq = _gaq || [];
_gaq.push(['_setAccount', 'UA-29701333-1']);
_gaq.push(['_trackPageview']);
(function() {
var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true;
ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js';
var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s);
})();
</script>
<body>
<!-- wrap starts here -->
<div id="wrap-out"><div id="wrap">
<!--header -->
<div id="header">
<h1 id="logo-text"><a href="http://www.thepharmajournal.com/" title="">The Pharma Innovation</a></h1>
<div id="nav">
<ul>
<li id="current"><a href="../index.html">Home</a></li>
<li><a href="../Editorial_Board.html">Editorial Board</a></li>
<li><a href="../archives.html">archives</a></li>
<li><a href="../instructions.html">instruction to authors</a></li>
<li></li>
<li><a href="../contact_us.html">contact us</a></li>
</ul>
</div>
<!--header ends-->
</div>
<!-- content-wrap starts -->
<div id="content-wrap">
<div id="main">
<h2 align="center" class="style6">Volume <span class="style11">4</span>, Issue10</h2>
<h6 align="center" class="style1"><strong></strong><strong></strong><strong></strong><strong>Preparation and <em>in-vitro</em> evaluation of nifedipine amorphous solid dispersions using mesoporous silica gel</strong><br />
</h6>
<p><strong>Author:</strong> Bhargavi L, Prathusha P, Belsen David, Yogesh S Chaudhari, Uppendra Reddy, Ajith Patil, Fred Monsuur</p>
<p><span class="style10">Abstract: </span>The main purpose of this study was to increase the solubility of poorly soluble drug by preparing solid dispersions. Nifedipine (poorly water soluble drug), when prepared as solid dispersion showed increased solubility and dissolution rate. Solid dispersions of Nifedipine were prepared by using silsol 6035 as carrier in various proportions 10%, 20% and 30% by solvent loading (solvent droplet addition)method and various grades of silica by co-milling method in ratios of (1:1, 1:2 and 2:1). The drug carrier interactions were carried out using Differential Scanning Calorimetry (DSC). Drug release and dissolution profile was studied and it was found that the percentage release of the drug for solid dispersions samples was found to be higher than those of the pure milled drug and co-milled powders. </p>
<p><span class="style10">Download Full Article:</span> <strong><a href="Issue_Dec_2015/4-10-1.1.pdf">Click Here </a></strong></p>
<p> </p>
<h3><strong>Support Us</strong></h3>
<p class="style5">If you are interested in supporting our work and would like to contribute, you are
welcome to mail me at jpbr.anil@gmail.com or at info@thepharmajournal.com it will
be a great help and will surely be appreciated.</p>
<p class="style5"><a href="http://www.phytojournal.com/" target="_blank"><img src="images/headerphoto70.jpg" alt="Advertisement" width="532" height="146" /></a></p>
<p> </p>
</div>
<!-- sidebar starts -->
<div id="sidebar">
<h3 class="style4"><a href="http://www.phytojournal.com/" target="_blank"><span class="style12"><span class="style13">Call Us: (Helpline)<br />
Toll Free (India):</span> <span class="style5">1800-1234-070<br />
<span class="style13">India:</span> +91-9711224068<br />
<span class="style13">Rest of World:</span> +91-9810852116</span></span></a></h3>
<h3 class="style4">ISSN 2277-7596</h3>
<h3><a href="http://www.phytojournal.com/" target="_blank"><img src="images/cognosy.jpg" alt="Pharmacognosy Journal" width="206" height="146" longdesc="http://www.phytojournal.com/" /></a></h3>
<h3>Journal code(s)</h3>
<p class="style3">ISSN Number: <span class="style5">2277-7695</span><br />
CODEN Code: <span class="style5">PIHNBQ</span><br />
ZDB-Number: <span class="style5">2663038-2 </span><br />
IC Journal ID: <span class="style5">7725</span></p>
<h3>Sidebar Menu</h3>
<ul class="sidemenu">
<li><a href="http://www.thepharmajournal.com/">Home</a></li>
<li><a href="http://www.thepharmajournal.com/Editorial_Board.html">Editorial Board</a></li>
<li><a href="http://www.thepharmajournal.com/archives.html">Archives</a></li>
<li><a href="http://www.thepharmajournal.com/instructions.html">Instructions to Author</a></li>
<li><a href="http://www.thepharmajournal.com/indexing.html" title="Web Templates">Indexing and Abstracting</a></li>
<li><a href="http://thepharmajournal.com/publication_fee.html">Publication Fee</a></li>
<li><a href="http://www.thepharmajournal.com/contact_us.html" title="Web Templates">Contact Us</a></li>
</ul>
<h3>Wise Words</h3>
<p class="style5">"You will not be punished for your anger, you will be punished by your anger." by <span class="style4">Buddha</span>.
<!-- sidebar ends -->
</p>
<p class="style5"> </p>
</div>
<!-- content-wrap ends-->
</div>
<!-- footer starts here -->
<div id="footer-wrap">
<div id="footer-content">
<div class="col float-left space-sep">
<h3>Important Links</h3>
<p><a href="http://www.thepharmajournal.com/important_links.html" title="The Pharma Innovation">Important Links</a></p>
<p><a href="http://www.thepharmajournal.com/Payment_Options.html">Payment Options</a></p>
<p><a href="http://www.thepharmajournal.com/archives.html">Archives</a></p>
</div>
<div class="col float-left">
<h3> </h3>
<p><a href="http://www.thepharmajournal.com/Advertise_with_us.html" title="The Pharma Innovation">Advertise With Us</a></p>
<p><a href="http://www.thepharmajournal.com/certificate.html">Certificate</a></p>
<p><a href="http://www.thepharmajournal.com/Disclaimer.html" title="The Pharma Innovation">Disclaimer</a><a href="http://www.thepharmajournal.com/" title="The Pharma Innovation"></a></p>
<p> </p>
<p align="center"><span class="style5">© copyright 2012 <strong>The Pharma Innovation</strong></span></p>
</div>
<div class="col2 float-right">
<h3> </h3>
<p><a href="http://www.thepharmajournal.com/indexing.html" title="The Pharma Innovation">Abstracting and Indexing</a></p>
<p><a href="http://www.thepharmajournal.com/sitemap.html" title="The Pharma Innovation">Site Map</a></p>
<p><a href="http://www.thepharmajournal.com/contact_us.html" title="The Pharma Innovation">Contact us</a></p>
</div>
</div>
</div>
<div class="clearer"></div>
<!-- footer ends here -->
<!-- wrap ends here -->
</div></div>
</body>
</html>