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<meta name="Description" content="In this study methanolic extract of Mimosa pudica (Mimosaceae) leaves was investigated to evaluate its antioxidant and toxic properties. Antioxidant activity was evaluated using total phenol content, total antioxidant capacity, total flavonoid contents and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. The methanolic crude extract showed moderate antioxidant activity such as total flavonoid content was found to be 63.8 mg QE/g and total phenol content was 42.9 mg GAE/g. The total antioxidant capacity was expressed as ascorbic acid equivalents (AAE) and for leaf it was 5.038 mg/g AAE. DPPH scavenging activity was measured by comparing with ascorbic acid. Both leaf and ascorbic acid IC50 values were 126.71 and 20.13µg/ml, respectively. On the other hand, the cytotoxic activity of methanolic extract of leaf was evaluated using brine shrimp lethality bioassay. LC50 value of the methanolic leaf extract of Mimosa pudica was found to be 282.3495µg/ml and its showed lethality in a dose reliant conduct. In brine shrimp lethality bioassay, Mimosa pudica leaf showed significant source of anticancer compounds.
Purpose: To assess the safety and efficacy of using trans-radial approach (TRA) for percutaneous coronary intervention (PCI) and stenting of left main coronary artery (LMN) with over 80% stenosis in symptomatic patients.
Methods: We evaluated clinical outcomes of 170 consecutive patients with LM stenting in period between January 2007 and March 2014. The follow up period was 6 months. The baseline characteristics of the study group were: mean age was 62±10.3 years. Males were 133(78%). Acute coronary syndrome (ACSy) was present in 141(83%) of patients. Patients with ST-segment elevation (STEMI) were 27(16%), and non-STEMI in 19 (11%) and unstable angina (UA) in 93(55%). Cardiogenic shock was present in 2 patients (1.17%).
Results: Trans-radial access was used in 151(89%) of patients, trans-ulnar (TUA) in 10(6%) TFA in 9(5%), using 5F and 6F guiding catheters. Drug-eluting stents were used in 131(77%) of patients treated with standard medication regiment. GP IIB/IIIA inhibitors were administrated only in 7(4%) patients. All procedures were achieved with TIMI 3 flow. Ten patients (6%) died during hospital stay and there was no additional deaths during 6 months follow up period. Nine deaths (5%) were cardiac and one (1,7%) was dye severe gastric bleeding.
Conclusion: Trans-radial stenting of diseased and symptomatic left main is feasible and safe when were performed by experienced high-volume operators. Selection, evaluation of the patient as well as planning of the procedure is crucial.
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<meta name="keywords" content="Mimosa pudica, Antioxidant, DPPH Scavenging activity, Cytotoxicity, Brine shrimp lethality bioassay.
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<title>Evaluation of safety and efficacy of trans-radial steEvaluation of antioxidant and cytotoxic activity of methanolic extract of Mimosa pudica leaves</title>
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<h2 align="center" class="style6">Volume <span class="style11">3</span>, Issue <span class="style11">4</span></h2>
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<h6 align="center" class="style1"><strong>Evaluation of antioxidant and cytotoxic activity of methanolic extract of <em>Mimosa pudica </em>leaves</strong></h6>
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<p><span class="style10">Author: </span><span class="style5">Kamanashis Das, Md. Yasin, Nasir Uddin Mahbub, Md. Shahidul Islam, Nayma Mahbuba <br />
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<p><span class="style10">Abstract:</span> <span class="style5">In this study methanolic extract of <em>Mimosa pudica (</em>Mimosaceae) leaves was investigated to evaluate its antioxidant and toxic properties. Antioxidant activity was evaluated using total phenol content, total antioxidant capacity, total flavonoid contents and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. The methanolic crude extract showed moderate antioxidant activity such as total flavonoid content was found to be 63.8 mg QE/g and total phenol content was 42.9 mg GAE/g. The total antioxidant capacity was expressed as ascorbic acid equivalents (AAE) and for leaf it was 5.038 mg/g AAE. DPPH scavenging activity was measured by comparing with ascorbic acid. Both leaf and ascorbic acid IC50 values were 126.71 and 20.13µg/ml, respectively. On the other hand, the cytotoxic activity of methanolic extract of leaf was evaluated using brine shrimp lethality bioassay. LC50 value of the methanolic leaf extract of <em>Mimosa pudica </em>was found to be 282.3495µg/ml and its showed lethality in a dose reliant conduct. In brine shrimp lethality bioassay, <em>Mimosa pudica</em> leaf showed significant source of anticancer compounds.</span></p>
<p><img src="images/7.1.jpg" alt="Fig: Graphical representation of cytotoxic activity of crude extracts on shrimp nauplii of Mimosa pudica leaves by brine Shrimp lethality bioassay method." width="470" height="239" /></p>
<p><span class="style5"><strong>Fig:</strong> Graphical representation of cytotoxic activity of crude extracts on shrimp nauplii of <em>Mimosa pudica </em>leaves by brine Shrimp lethality bioassay method.</span></p>
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