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<h2 align="center" class="style6">Volume <span class="style11">3</span>, Issue <span class="style11">10</span></h2>
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<h6 align="center" class="style1"><strong>Microwave assisted synthesis of some pyrazole derivatives and their antibacterial and antifungal activity</strong></h6>
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<p><span class="style10">Author: </span><span class="style5">Deepak Swarnkar, Rakshit Ameta, Ritu Vyas</span></p>
<p><span class="style10">Abstract: </span><span class="style5">In the present investigation, microwave assisted synthesis of 3-(4-substituted phenyl)-1-phenylprop-2-en-1-ones (Chalcones) <strong>(1a-c)</strong> were synthesized by base catalyzed aldol condensation of p-substituted benzaldehyde with acetophenone in the presence of piperidine.</span></p>
<p><span class="style5">3-(4-substituted phenyl)-1-phenylprop-2-en-1-one (Chalcones) <strong>(1a-c)</strong> was carried out with hydrazine hydrate, phenyl hydrazine, isoniazid, nicotinic hydrazide or thiosemicarbezide in ethanol containing a few drops of glacial acetic acid under microwave irradiation giving 3-(4-substituted phenyl)-5-phenyl-2,3-dihydro-1<em>H</em>-pyrazole <strong>(2a-c)</strong>, 3-(4-substituted phenyl)-2-5-diphenyl-2,3-dihydro-1<em>H</em>-pyrazole <strong>(3a-c)</strong>, [5-(4-substituted phenyl)-3-phenyl-2,5-dihydro-1<em>H</em>-pyrazole-1-yl](pyridine-4-yl)methanone <strong>(4a-c),</strong> [5-(4-substituted phenyl)-3-phenyl-2,5-dihydro-1<em>H</em>-pyrazole-1-yl](pyridine-3-yl)methanone <strong>(5a-c)</strong>, 5-(4-substituted phenyl)-3-phenyl-2,5-dihydro-1<em>H</em>-pyrazole-1-carbothioamide <strong>(6a-c)</strong> derivatives. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR and 1H NMR spectral data. The synthesized compounds have been screened for their antibacterial and antifungal activities.</span></p>
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