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<meta name="Description" content="Anxiety is a psychological disorder, which alters the behavior of an individual. Taking into view, about the current status of anxiety, it is the time for researcher to look into it quiet seriously and to come up with novel therapeutics. Hence, with this perspective, the present study was designed to investigate the anxiolytic profile of a novel 5-HT3 receptor antagonist 4a by using behavioral models of anxiety in mice like, EPM, OFT, LD and HBT." />
<meta name="keywords" content="5-HT3 Receptor, Anxiety, Elevated Plus Maze, Open Field Test, 4a."/>
<title>Anxiolytic Effect of a Novel 5-HT3 Receptor Antagonist (4-Phenylpiperazin-1-yl) (Quinoxalin-2-yl) Methanone (4a) in a Battery of Behavioral Models for Anxiety in Mice.</title>
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<h2 align="center" class="style6">Volume <span class="style11">2</span>, Issue 6</h2>
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<h6 align="center" class="style1">Anxiolytic Effect of a Novel 5-HT3 Receptor Antagonist (4-Phenylpiperazin-1-yl) (Quinoxalin-2-yl) Methanone (4a) in a Battery of Behavioral Models for Anxiety in Mice </h6>
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<p><span class="style10">Authors: </span><span class="style5">Yeshwant Vijay Kurhe*, Mahesh Radhakrishnan, Deepali Gupta, Devodoss Thangaraj<br />
Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan-333031, India.</span></p>
<p><span class="style10">Abstract:</span> <span class="style5">The serotonergic system of brain is well understood to play a crucial role in emotional processing in human and animals. 5-HT3 receptor, the ion channel type of receptor is involved in mood, anxiety, depression, learning and memory. Objective of the present work was to investigate the anxiolytic potential of a novel 5-HT3 receptor antagonist (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a) in mice. Different behavioral test paradigms for anxiety like elevated plus maze, open field test, light-dark model and hole board test were used for assessing the effect. Diazepam 2 mg/kg i.p. served as a reference standard. From the results it was found that 4a dose dependently at 2 and 4 mg/kg i.p. attenuated the behavioral alterations in the anxiety models in mice. The exact mechanism of 5-HT3 receptor antagonist for anxiolytic potential is still ill understood. Our further studies will deal with mechanisms at molecular levels for anxiolytic potential of 4a.</span></p>
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