| Server IP : 192.169.170.185 / Your IP : 216.73.216.97 Web Server : Apache System : Linux p3plmcpnl495852.prod.phx3.secureserver.net 4.18.0-553.52.1.lve.el8.x86_64 #1 SMP Wed May 21 15:31:29 UTC 2025 x86_64 User : akhilnew ( 1712764) PHP Version : 5.6.40 Disable Function : NONE MySQL : ON | cURL : ON | WGET : ON | Perl : ON | Python : ON | Sudo : OFF | Pkexec : OFF Directory : /home/akhilnew/public_html/thepharmajournal/vol2Issue1/ |
Upload File : |
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Strict//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-strict.dtd">
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
<head>
<meta name="Description" content="Sustained release systems include any drug delivery system that achieves slow release of drug over an extended period of time. If the system is successful in maintaining constant drug levels in the blood or target tissue, it is considered as a controlled release system. If it unsuccessful at this but nevertheless extends the duration of action over that achieved by conventional delivery, it is considered as a prolonged release system. " />
<meta name="keywords" content="Sustained Release Tablet; Cyproheptadine Hydrochloride; Optimization; Carbopol; HPMC."/>
<title>Preparation and Evaluation of Sustained Release Tablet of Cyproheptadine Hydrochloride Using Carbopol and HPMC</title>
<meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1" />
<meta name="Distribution" content="Global" />
<meta name="Author" content="Erwin Aligam - ealigam@gmail.com" />
<meta name="Robots" content="index,follow" />
<link rel="stylesheet" href="images/FreshMedia.css" type="text/css" />
<style type="text/css">
<!--
.style1 {
font-size: 16px;
color: #FF0033;
}
.style4 {color: #FF0033}
.style5 {color: #000000}
.style3 {
color: #FF0000;
font-weight: bold;
}
.style6 {
color: #000000;
font-weight: bold;
}
.style7 {color: #FFFFFF}
.style8 {color: #009966}
.style10 {color: #FF0033; font-weight: bold; }
.style11 { font-size: 14px;
font-weight: bold;
}
.style11 {color: #FF0000}
-->
</style>
</head>
<script type="text/javascript">
var _gaq = _gaq || [];
_gaq.push(['_setAccount', 'UA-29701333-1']);
_gaq.push(['_trackPageview']);
(function() {
var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true;
ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js';
var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s);
})();
</script>
<body>
<!-- wrap starts here -->
<div id="wrap-out"><div id="wrap">
<!--header -->
<div id="header">
<h1 id="logo-text"><a href="http://www.thepharmajournal.com/" title="">The Pharma Innovation</a></h1>
<div id="nav">
<ul>
<li id="current"><a href="../index.html">Home</a></li>
<li><a href="../Editorial_Board.html">Editorial Board</a></li>
<li><a href="../archives.html">archives</a></li>
<li><a href="../instructions.html">instruction to authors</a></li>
<li></li>
<li><a href="../contact_us.html">contact us</a></li>
</ul>
</div>
<!--header ends-->
</div>
<!-- content-wrap starts -->
<div id="content-wrap">
<div id="main">
<h2 align="center" class="style6">Volume 2, Issue 1</h2>
<p> </p>
<h6 align="center" class="style1">Preparation and Evaluation of Sustained Release Tablet of Cyproheptadine Hydrochloride Using Carbopol and HPMC</h6>
<p> </p>
<p><span class="style10">Author:</span><span class="style5"> Vaibhav Gadade*, Ganesh Rasal , D. shivarkar<br />
ACS’S College of Pharmacy, Ashti, Beed, India.</span></p>
<p><span class="style10">Abstract:</span> <span class="style5">In the present work, an attempt was made to formulate sustained release tablets for antihistaminic drug Cyproheptadine hydrochloride using Carbopol 934 and HPMC E15. The tablets were prepared by direct compression process. A 32 full factorial design was employed for the optimization of developed formulation considering concentration of carbopol 934 and HPMC E15 as independent variables with drug release as dependent variables. The developed formulations showed uniform thickness, average weight, adequate hardness, drug content and friability. In vitro drug release study was carried out in simulated gastric fluid (0.1 N HCl) for the first 2 h and in phosphate buffer (pH 6.8) for the next 10 h. It can be seen that by increasing the polymers concentration, the rate of drug released from the tablet decreased dramatically. Design expert software® was used to give the solution for optimized formulation based on the evaluation of the developed formulations. Stability studies (40±2 ºC/ 75±5%RH) for 3 months indicated that no appreciable difference was observed for the drug content and drug release.</span></p>
<p><span class="style10">Download Full Article</span><span class="style10">:</span> <strong><a href="Issue_march_2013/16.pdf">Click Here </a></strong></p>
<p> </p>
<h3><strong>Support Us</strong></h3>
<p class="style5">If you are interested in supporting our work and would like to contribute, you are
welcome to mail me at jpbr.anil@gmail.com or at info@thepharmajournal.com it will
be a great help and will surely be appreciated.</p>
<p class="style5"><a href="http://www.phytojournal.com/"><img src="images/headerphoto70.jpg" alt="Advertisement" width="532" height="146" /></a></p>
<p> </p>
</div>
<!-- sidebar starts -->
<div id="sidebar">
<h3 class="style4"><a href="http://www.phytojournal.com/" target="_blank"><span class="style11">Call Us: (Helpline)<br />
Toll Free (India): <span class="style5">1800-1234-070<br />
India: +91-9711224068<br />
Rest of World: +91-9810852116</span></span></a></h3>
<h3 class="style4">ISSN 2277-7596</h3>
<p class="style4"><strong>Advertisement</strong><br />
</p>
<h3><a href="http://www.phytojournal.com/" target="_blank"><img src="images/cognosy.jpg" alt="Pharmacognosy Journal" width="206" height="146" longdesc="http://www.phytojournal.com/" /></a></h3>
<h3>Journal code(s)</h3>
<p class="style3"><strong><span class="style5">ISSN Number:</span> 2277-7695</strong></p>
<p class="style3"><span class="style5">CODEN Code:</span> PIHNBQ</p>
<p class="style3"><span class="style5">ZDB-Number:</span> 2663038-2 </p>
<p class="style3"><span class="style5">IC Journal ID:</span> 7725</p>
<h3>Sidebar Menu</h3>
<ul class="sidemenu">
<li><a href="http://www.thepharmajournal.com/">Home</a></li>
<li><a href="http://www.thepharmajournal.com/Editorial_Board.html">Editorial Board</a></li>
<li><a href="http://www.thepharmajournal.com/archives.html">Archives</a></li>
<li><a href="http://www.thepharmajournal.com/instructions.html">Instructions to Author</a></li>
<li><a href="http://www.thepharmajournal.com/indexing.html" title="Web Templates">Indexing and Abstracting</a></li>
<li><a href="http://thepharmajournal.com/publication_fee.html">Publication Fee</a></li>
<li><a href="http://www.thepharmajournal.com/contact_us.html" title="Web Templates">Contact Us</a></li>
</ul>
<h3>Wise Words</h3>
<p class="style5">"You will not be punished for your anger, you will be punished by your anger." by <span class="style4">Buddha</span>.
<!-- sidebar ends -->
</p>
</div>
<!-- content-wrap ends-->
</div>
<!-- footer starts here -->
<div id="footer-wrap">
<div id="footer-content">
<div class="col float-left space-sep">
<h3>Important Links</h3>
<p><a href="http://www.thepharmajournal.com/important_links.html" title="The Pharma Innovation">Important Links</a></p>
<p><a href="http://www.thepharmajournal.com/Payment_Options.html">Payment Options</a></p>
<p><a href="http://www.thepharmajournal.com/archives.html">Archives</a></p>
</div>
<div class="col float-left">
<h3> </h3>
<p><a href="http://www.thepharmajournal.com/Advertise_with_us.html" title="The Pharma Innovation">Advertise With Us</a></p>
<p><a href="http://www.thepharmajournal.com/certificate.html">Certificate</a></p>
<p><a href="http://www.thepharmajournal.com/Disclaimer.html" title="The Pharma Innovation">Disclaimer</a><a href="http://www.thepharmajournal.com/" title="The Pharma Innovation"></a></p>
<p> </p>
<p align="center"><span class="style5">© copyright 2012 <strong>The Pharma Innovation</strong></span></p>
</div>
<div class="col2 float-right">
<h3> </h3>
<p><a href="http://www.thepharmajournal.com/indexing.html" title="The Pharma Innovation">Abstracting and Indexing</a></p>
<p><a href="http://www.thepharmajournal.com/sitemap.html" title="The Pharma Innovation">Site Map</a></p>
<p><a href="http://www.thepharmajournal.com/contact_us.html" title="The Pharma Innovation">Contact us</a></p>
</div>
</div>
</div>
<div class="clearer"></div>
<!-- footer ends here -->
<!-- wrap ends here -->
</div></div>
</body>
</html>