| Server IP : 192.169.170.185 / Your IP : 216.73.216.97 Web Server : Apache System : Linux p3plmcpnl495852.prod.phx3.secureserver.net 4.18.0-553.52.1.lve.el8.x86_64 #1 SMP Wed May 21 15:31:29 UTC 2025 x86_64 User : akhilnew ( 1712764) PHP Version : 5.6.40 Disable Function : NONE MySQL : ON | cURL : ON | WGET : ON | Perl : ON | Python : ON | Sudo : OFF | Pkexec : OFF Directory : /home/akhilnew/public_html/thepharmajournal/vol2Issue1/ |
Upload File : |
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Strict//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-strict.dtd">
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
<head>
<meta name="Description" content="Punica granatum exhibits pleiotropic cardiac effects in PAAC-induced cardiac hypertrophy in a dose-dependent manner possibly through its PPAR (Peroxisome proliferator activated receptor) dual agonist action." />
<meta name="keywords" content="Aortic Constriction, Cardiac Hypertrophy, Punica granatumor"/>
<title>Implication of Punica granatum Leaves in Experimental Cardiac Hypertrophy</title>
<meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1" />
<meta name="Distribution" content="Global" />
<meta name="Author" content="Erwin Aligam - ealigam@gmail.com" />
<meta name="Robots" content="index,follow" />
<link rel="stylesheet" href="images/FreshMedia.css" type="text/css" />
<style type="text/css">
<!--
.style1 {
font-size: 16px;
color: #FF0033;
}
.style4 {color: #FF0033}
.style5 {color: #000000}
.style3 {
color: #FF0000;
font-weight: bold;
}
.style6 {
color: #000000;
font-weight: bold;
}
.style7 {color: #FFFFFF}
.style8 {color: #009966}
.style10 {color: #FF0033; font-weight: bold; }
.style11 { font-size: 14px;
font-weight: bold;
}
.style11 {color: #FF0000}
-->
</style>
</head>
<script type="text/javascript">
var _gaq = _gaq || [];
_gaq.push(['_setAccount', 'UA-29701333-1']);
_gaq.push(['_trackPageview']);
(function() {
var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true;
ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js';
var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s);
})();
</script>
<body>
<!-- wrap starts here -->
<div id="wrap-out"><div id="wrap">
<!--header -->
<div id="header">
<h1 id="logo-text"><a href="http://www.thepharmajournal.com/" title="">The Pharma Innovation</a></h1>
<div id="nav">
<ul>
<li id="current"><a href="../index.html">Home</a></li>
<li><a href="../Editorial_Board.html">Editorial Board</a></li>
<li><a href="../archives.html">archives</a></li>
<li><a href="../instructions.html">instruction to authors</a></li>
<li></li>
<li><a href="../contact_us.html">contact us</a></li>
</ul>
</div>
<!--header ends-->
</div>
<!-- content-wrap starts -->
<div id="content-wrap">
<div id="main">
<h2 align="center" class="style6">Volume 2, Issue 1</h2>
<p> </p>
<h6 align="center" class="style1"> Implication of <em>Punica granatum</em> Leaves in Experimental Cardiac Hypertrophy </h6>
<p> </p>
<p><span class="style10">Author:</span><span class="style5"> Rohini A. *, Neeraj Agrawal , M.J.N. Chandrasekar3, U.V.S. Sara<br />
United Institute of Pharmacy, Allahabad, U.P., India </span></p>
<p><span class="style10">Abstract:</span> <span class="style5">The present study has been designed to explore the beneficial effect of <em>Punica grantum</em> leaves in experimental cardiac hypertrophy in rats. <em>Punica granatum</em> L., (Family: Punicaceae) is used in Indian Unani medicine for treatment of diabetes mellitus, cytotoxixity and in wound healing owing to its anti-oxidant activity. The male wistar rats were anaesthetized with thiopentone sodium and were subjected to Partial Abdominal Aortic Constriction (PAAC) for 4 weeks. The treatment with ethanolic extract of leaves of <em>P.</em> <em>granatum</em> (EPG) (200 mg/kg and 400 mg/kg) was started three days before surgery and it was continued for 4 weeks after surgery. The development of left ventricular (LV) hypertrophy was assessed by measuring ratio of LV weight to body weight (LVW/BW), LV wall thickness (LVWT), LV protein content, LV collagen content and LV RNA concentration. Further mean arterial blood pressure (MABP) was recorded. Moreover, oxidative stress in heart was measured by CK-MB and LDH estimation. The PAAC significantly increased the ratio of LV weight to body weight, LV wall thickness, LV protein content, LV collagen content and LV RNA concentration. Further PAAC significantly increased MABP and oxidative stress. The EPG (400 mg/kg) markedly attenuated PAAC induced increase in LV hypertrophy, MABP and LV oxidative stress. These results implicate the role of <em>Punica granatum</em> leaves in PAAC induced oxidative stress and pathological cardiac hypertrophy</span></p>
<p><span class="style10">Download Full Article</span><span class="style10">:</span> <strong><a href="Issue_march_2013/12.pdf">Click Here </a></strong></p>
<p> </p>
<h3><strong>Support Us</strong></h3>
<p class="style5">If you are interested in supporting our work and would like to contribute, you are
welcome to mail me at jpbr.anil@gmail.com or at info@thepharmajournal.com it will
be a great help and will surely be appreciated.</p>
<p class="style5"><a href="http://www.phytojournal.com/"><img src="images/headerphoto70.jpg" alt="Advertisement" width="532" height="146" /></a></p>
<p> </p>
</div>
<!-- sidebar starts -->
<div id="sidebar">
<h3 class="style4"><a href="http://www.phytojournal.com/" target="_blank"><span class="style11">Call Us: (Helpline)<br />
Toll Free (India): <span class="style5">1800-1234-070<br />
India: +91-9711224068<br />
Rest of World: +91-9810852116</span></span></a></h3>
<h3 class="style4">ISSN 2277-7596</h3>
<p class="style4"><strong>Advertisement</strong><br />
</p>
<h3><a href="http://www.phytojournal.com/" target="_blank"><img src="images/cognosy.jpg" alt="Pharmacognosy Journal" width="206" height="146" longdesc="http://www.phytojournal.com/" /></a></h3>
<h3>Journal code(s)</h3>
<p class="style3"><strong><span class="style5">ISSN Number:</span> 2277-7695</strong></p>
<p class="style3"><span class="style5">CODEN Code:</span> PIHNBQ</p>
<p class="style3"><span class="style5">ZDB-Number:</span> 2663038-2 </p>
<p class="style3"><span class="style5">IC Journal ID:</span> 7725</p>
<h3>Sidebar Menu</h3>
<ul class="sidemenu">
<li><a href="http://www.thepharmajournal.com/">Home</a></li>
<li><a href="http://www.thepharmajournal.com/Editorial_Board.html">Editorial Board</a></li>
<li><a href="http://www.thepharmajournal.com/archives.html">Archives</a></li>
<li><a href="http://www.thepharmajournal.com/instructions.html">Instructions to Author</a></li>
<li><a href="http://www.thepharmajournal.com/indexing.html" title="Web Templates">Indexing and Abstracting</a></li>
<li><a href="http://thepharmajournal.com/publication_fee.html">Publication Fee</a></li>
<li><a href="http://www.thepharmajournal.com/contact_us.html" title="Web Templates">Contact Us</a></li>
</ul>
<h3>Wise Words</h3>
<p class="style5">"You will not be punished for your anger, you will be punished by your anger." by <span class="style4">Buddha</span>.
<!-- sidebar ends -->
</p>
</div>
<!-- content-wrap ends-->
</div>
<!-- footer starts here -->
<div id="footer-wrap">
<div id="footer-content">
<div class="col float-left space-sep">
<h3>Important Links</h3>
<p><a href="http://www.thepharmajournal.com/important_links.html" title="The Pharma Innovation">Important Links</a></p>
<p><a href="http://www.thepharmajournal.com/Payment_Options.html">Payment Options</a></p>
<p><a href="http://www.thepharmajournal.com/archives.html">Archives</a></p>
</div>
<div class="col float-left">
<h3> </h3>
<p><a href="http://www.thepharmajournal.com/Advertise_with_us.html" title="The Pharma Innovation">Advertise With Us</a></p>
<p><a href="http://www.thepharmajournal.com/certificate.html">Certificate</a></p>
<p><a href="http://www.thepharmajournal.com/Disclaimer.html" title="The Pharma Innovation">Disclaimer</a><a href="http://www.thepharmajournal.com/" title="The Pharma Innovation"></a></p>
<p> </p>
<p align="center"><span class="style5">© copyright 2012 <strong>The Pharma Innovation</strong></span></p>
</div>
<div class="col2 float-right">
<h3> </h3>
<p><a href="http://www.thepharmajournal.com/indexing.html" title="The Pharma Innovation">Abstracting and Indexing</a></p>
<p><a href="http://www.thepharmajournal.com/sitemap.html" title="The Pharma Innovation">Site Map</a></p>
<p><a href="http://www.thepharmajournal.com/contact_us.html" title="The Pharma Innovation">Contact us</a></p>
</div>
</div>
</div>
<div class="clearer"></div>
<!-- footer ends here -->
<!-- wrap ends here -->
</div></div>
</body>
</html>